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GLP-1 and GIP/GLP-1 receptor agonists require refrigeration between 36F and 46F (2C to 8C) until first use
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6, Supplementary Fig
Literature on this topic is too large to summarise comprehensively, but it suffices to say that GLP1R agonists are capable of increasing the activity of neurons that promote satiety, while simultaneously decreasing the activity of neurons that promote hunger
Most people notice reduced appetite and quieter cravings within the first two to four weeks, as the four-week dose titration reaches full strength
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